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Dernières entêtes d'Actus

ORIGINAL ARTICLE: Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
Rivaroxaban is an orally administered direct inhibitor of factor Xa. As compared with enoxaparin, rivaroxaban was more effective in preventing venous thromboembolism after hip replacement, without a significant increase in major bleeding.

ORIGINAL ARTICLE: Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Total Knee Arthroplasty
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
This trial compared rivaroxaban with enoxaparin for thromboprophylaxis after total knee replacement. Rivaroxaban was superior to enoxaparin in the prevention of venous thrombosis, and the two drugs had similar safety profiles.

ORIGINAL ARTICLE: Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
Murine studies suggest that aortic-root dilation in Marfan's syndrome is due to excessive signaling by transforming growth factor {beta} (TGF-{beta}) and can be mitigated by TGF-{beta} antagonists, such as angiotensin II-receptor blockers (ARBs). This study reviewed data on 18 pediatric patients with Marfan's syndrome who had begun ARB therapy and had been followed for at least 12 months. The rate of increase in aortic-root diameter was significantly slowed after the initiation of ARB therapy.

SPECIAL ARTICLE: Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide polymorphisms with a strong statistical association with breast cancer. Individually, these alleles are associated with a small relative risk, but when combined, they could facilitate population-based screening for breast cancer.

CLINICAL PRACTICE: Acute Calculous Cholecystitis
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
A 42-year-old woman presents with severe pain in the right upper quadrant, which started 15 hours earlier. She has had episodic pain in that location previously that lasted up to 2 hours. She has had one episode of vomiting with the current attack. Her temperature is 38.5{degrees}C, and the heart rate is 95 beats per minute. How should her condition be evaluated and treated?

VIDEOS IN CLINICAL MEDICINE: Placement of a Femoral Venous Catheter
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
Figure A femoral venous catheter may be necessary when peripheral access to the circulatory system is compromised and no other sites for placing a central catheter are available. This video demonstrates the insertion of a femoral venous catheter and explains the indications and potential complications.

IMAGES IN CLINICAL MEDICINE: Systemic Sclerosis and Acral Osteolysis
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
A 71-year-old woman received a diagnosis of systemic sclerosis more than 30 years ago when she presented with Raynaud's phenomenon and cutaneous sclerosis. At that time she did not require ...

IMAGES IN CLINICAL MEDICINE: Spontaneous Thrombolysis of an Obstructed Mechanical Aortic Valve
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
A 28-year-old man with idiopathic dilated cardiomyopathy who had had St. Jude aortic- and mitral-valve replacements 3 years earlier presented with decompensated heart failure. The examination was notable for marked ...

CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL: Case 20-2008 -- A 57-Year-Old Woman with Abdominal Pain and Weakness after Gastric Bypass Surgery
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
A 57-year-old woman was admitted to the hospital because of abdominal pain and weakness, 1 month after gastric bypass surgery. In the month after the operation, episodes of tachycardia, bradycardia, diarrhea, dark urine, and abdominal pain occurred, with urine cultures that were positive for bacteria. After admission, weakness and numbness in the legs and arms developed and progressed to flaccid quadriparesis. A diagnostic test was performed.

EDITORIAL: New Anticoagulants -- The Path from Discovery to Clinical Practice
Mercredi 25 Juin 2008 - 06:55 - 5 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
For more than half a century, heparin and vitamin K antagonists have defined anticoagulant therapy for the short-term and long-term management, respectively, of thrombotic disorders of the venous system. The ...

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